PhD defended

/PhD defended
PhD defended 2018-02-06T13:49:20+00:00

Stéphanie Sidorkiewicz
Thesis defended in 2017

Stéphanie Sidorkiewicz

Medication adherence among patients taking long-term treatments

Supervisors : Philippe Ravaud and Viet-Thi Tran

This doctoral thesis focused on medication adherence among patients with one or several chronic conditions and taking multiple medications.
The first PhD project was the development of an instrument to assess medication adherence, with a “drug by drug” perspective. Validity and reliability of the tool were tested among 243 patients in France. The two other projects focused on the discordance between patients’ and physicians’ points of view about medication importance and on the estimation of the threshold for unacceptable risk of non-adherence according to 544 physicians for the most prescribed drugs in France. The results suggested a huge variation in physicians’ estimations according to the drug of interest.

Ignacio Atal
Thesis defended in 2017

Ignacio Atal

World maping of clinical trials

Supervisor : Raphaël Porcher and Ludovic Trinquart

In this thesis we mapped registered clinical trials at a macro-level, i.e. we analyzed what clinical research is undertaken worldwide, where it is conducted, which diseases are studied, and who is supporting it.
We highlighted major gaps in the effort of health research as compared to health needs, and the influence of different sponsors in the globalization of clinical research.

Lee Aymar Ndounga Diakou
Thesis defended in 2017

Lee Aymar Ndounga

Implementation of Results of Randomized Trials in Sub-Saharan Africa

Supervisor : Isabelle Boutron

Thesis of Lee Aymar Ndoundga

We found that SSA RCTs investigate locally high burdened diseases, however these trials are frequently led by high income countries.
Moreover, SSA RCTs at high risk of biais could be changed in trials at low risk of bias with simple methodological adjustments of minor cost, and the completeness of the intervention description could be improved with the adherence to CONSORT guidelines.

Romana Haneef
Thesis defended in 2017

Romana Haneef

Dissemination and communication of clinical research evaluating treatments

Supervisor : Isabelle Boutron

Thesis of Romana Haneef

This thesis assessed the prevalence of spin in Google Health news, classified different strategies of spin and identified that factors related to publication process were associated with high dissemination through online media. This work highlighted the importance of spin in mass media and provided a tool (classification of spin) to improve the dissemination and communication of research results.

Alexandre Vivot
Thesis defended in 2017

Alexandre Vivot

Medicine in Oncology: Translation of Genetic Biomarkers Discoveries to the Clinic

Supervisor : Raphaël Porcher

Thesis of Alexandre Vivot

We analyzed all the FDA-approved drugs with a pharmacogenetic biomarker in their label and showed that (1) predictive biomarkers in the label of drugs is restricted in large part to oncology; (2) the level of evidence for clinical utility is often unknown because studies are restricted to the subgroup of biomarker-positive patients from the initial stages of the drug development; (3) there are very important variations between drugs in the use of enriched trials and in testing of the drug in several indications or with several predictive biomarker; and finally (4) that only one third of the anti-cancer drugs approved by the FDA between 2000 and 2015 have meaningful clinical benefit.

Michaïl Kovanis
Thesis defended in 2017

Michail Kovanis

Modelling the complex system of scientific publication

Supervisors : Raphaël Porcher and Ludovic Trinquart

Thesis of Michail Kovanis

Phrase: In my PhD thesis, I modeled the macroscopic behavior of the scientific publication and peer-review systems, and I showed that the scientific community can collectively meet the annual demand for peer review, however, only 20% of researchers have been performing 69%-94% of reviews. Moreover, my results indicated that peer-review systems which allow sharing of past reviews of rejected manuscripts between journals showed important advantages, such as improved peer-review efficiency, less reviewer effort and better scientific dissemination.

Guillaume Lonjon
Thesis defended in 2017

Guillaume Lonjon

Use of propensity score in observational studies in surgery. Description, comparison, bias

Supervisor : Isabelle Boutron

Thesis of Guillaume Lonjon

In this project, I aimed to 1) compare treatment effect estimates from non-randomized studies with PS analysis and RCTs and 2) describe and assess the reporting and potential bias of PS analysis used in a sample of published observational studies assessing surgical procedures.

Céline Buffel du Vaure
Thesis defended in 2016

Evidence-Based-Medicine limits for management of multimorbidity in General Practice

Supervisor : Isabelle Boutron

Perrine Crequit
Thesis defended in 2016

Perrine Crequit

Network meta-analysis and oncolog

Supervisor : Philippe Ravaud and Ludovic Trinquart

Thesis of Anne Rousseau

Systematic reviews are essential tools to synthesize available evidence for therapeutic evaluation. Multiple treatments are now frequently available for a given condition. Patients and physicians want to know which one is the best among all treatments. Thus we need to retrieve and synthesize all available evidence across all treatments and furthermore to maintain it updated when new evidence and new treatments become available.

Our objective was to evaluate the limits of the current ecosystem of evidence synthesis and to develop an alternative methodology.

Anne Rousseau
Thesis defended in 2016

Anne Rousseau

Immediate Postpartum hemorrhage severe. Analysis of environmental and organizational factors

Supervisor : Philippe Ravaud and Patrick Rozenberg

Thesis of Anne Rousseau

The objective of this PhD thesis was to develop and validate a methodology with dynamic case-vignette to study discrepancies with good practices and to assess determinants related to the organization of care and / or caregivers in postpartum hemorhage management.

Amélie Yavchitz
Thesis defended in 2015

Amelie Yavchitz

Dissemination of scientific findings from randomized controlled trials and systematic reviewss

Supervisor : Isabelle Boutron

Thesis of Amélie Yavchitz

An accurate and complete presentation by authors of all the important information in report of randomized controlled trial (RCT) and systematic reviews (SR) is essential to allow a critical appraisal of the study by readers. Spin was defined as a specific way of reporting, deliberate or not, that can lead to a “beautification” of the data. We showed that 1) spin are disseminated in press releases and news and they are associated with an overestimation of the beneficial effect of treatment, 2) the addition of a limitation section in abstract of systematic reviews and meta-analysis does not impact the confidence in the study results by readers. Finally, we developed a classification scheme of spin in systematic reviews and meta-analyzes, and we ranked spin in abstract according to their perceived severity

Clémence Palazzo
Thesis defended in 2016

Evaluation and improvement of qualitative compliance in rehabilitation

Supervisor : Philippe Ravaud and Serge Poiraudeau

Clarisse Dibao-Dina
Thesis defended in 2015

Unbalanced randomization and ambivalence clause

Supervisor : Bruno Giraudeau

Cécile Pino
Thesis defended in 2015

Educational interventions: Applicability of results and effectiveness of new forms of intervention

Supervisors : Philippe Ravaud and Isabelle Boutron

Viet-Thi Tran
Thesis defended in 2015

Viet-Thi Tran

Development of tools to measure treatment burden in patients with multiple chronic diseases

Supervisor : Philippe Ravaud

Thesis of Viet-Thi Tran

As chronic diseases are becoming more prevalent, their management strategies are becoming more complicated. Patients are feeling increasingly burdened by their treatments. This burden of treatment represents the “work of being a patient”. It affects treatment adherence, quality of life and outcomes. In order to take into account this burden, clinicians and researchers needed tools to assess it.

Aïda Bafeta
Thesis defended in 2015

Epidemiology and methodology of meta-analyzes network

Supervisor : Philippe Ravaud

Thesis of Aïda Bafeta

Network meta-analyses are primarily meta-analyses; they are probably subject to the same types of bias and should therefore be performed according to the explicit and rigorous methods used in systematic reviews. We assessed whether network meta-analyses follow the key methodological recommendations for reporting and conduct of systematic reviews, and how the results of network meta-analyses are reported.

Bénédicte Sautenet
Thesis defended in 2015

Assessment of outcomes heterogeneity in nephrology randomized trials: meta-epidemiological study

Supervisor : Bruno Giraudeau