Integration of Various Types of Information in Living Systematic Reviews
Supervisor: Isabelle Boutron and Anna Chaimani
Systematic reviews are mostly based on published randomized controlled trials (RCTs) i.e., the gold standard for therapeutic evaluation. However, information can be gained from other sources, particularly non-randomized studies, preprints, regulatory data as well as trial registry results data. There is also more access to post-publication and crowd-sourcing peer reviews. Therefore, how such data should be integrated in evidence synthesis raises important challenges.
We will use data from the Cochrane living systematic review and network meta-analysis (COVID-NMA) initiative (covid-nma.com). Firstly, we will evaluate the impact of integrating preprints in living systematic reviews. We will also assess the role of post-publication and crowd-sourcing peer reviews in the identification of methodological issues. Finally, we will evaluate the consistency of the results between early-stage observational studies and the results of meta-analyses of RCTs.