Network Meta-analysis

Clinical Trial Networks

Clinicaltrialnetworks.com is a library of networks of clinical trials assessing interventions in healthcare. Each network describes the amount of evidence comparing different interventions available to treat a given condition..

Live Cumulative Network Analysis

For many conditions, multiple competing treatments are available, many of which have been assessed in randomized trials. Clinicians and patients who are making medical decisions need to know which treatment works best among all treatments for the condition of interest. They increasingly use meta-analyses that synthesize the results of randomized trials to inform the relative efficacy and safety of the different treatments.
But conventional meta-analyses do not provide an exhaustive up-to-date synthesis of all available treatments, and thus prevent from answering easily to the real questions of interest. We propose to switch:

1. from a series of conventional meta-analyses focused on specific treatments (many treatments being not considered) to a single network meta-analysis covering all treatments; and
2. from meta-analyses performed at a given time and frequently out-of-date to a cumulative network meta-analysis systematically updated as soon as the results of a new trial become available

We call this approach “live cumulative network meta-analysis”.